Science of Holistic G-120

The world’s first anti-aging molecule (+)Syringaresinol was discovered from ginseng berry, which is the core ingredient in Holistic G-120. (+)Syringaresinol causes SIRT1 longevity gene expression and activates the SIRT1 protein.

www.impactaging.com

AGING, March 2013, Vol. 5 No 3

Identification of a small molecule activator of SIRT1 gene expression

Si-Young Cho 1*, Miook Cho 2*, Dae Bang Seo 1, Sang Jun Lee 1, and Yousin Suh 2,3,4

1 R&D Center, Amorepacific Corporation, Gyeonggi-do, Korea 446-729
2 Department of Genetics, Albert Einstein College of Medicine, Bronx NY 10461, USA
3 Department of Medicine, Albert Einstein College of Medicine, Bronx NY 10461, USA
4 Institue of Aging Research, Guangdong Medical College, Dongguan, China
* These authors contributed equally to this work

Key words : SIRT1; gene expression; small molecule activator; senescence; syringaresinol
Received : 12/10/12; Accepted: 3/5/13; published: 3/6/13
Correspondence to : Sang Jun lee, PhD; Yousin Suh, PhD;
E-mail : leesjun@amorepacific.com; yousin.suh@einstein.yu.edu

science

(+)Syringaresinol, the world’s first anti-aging molecule discovered from ginseng berry, shows potential to prevent heart attacks.

www.impactjournals.com/oncotarget

Oncotarget, Advance Publications 2014

Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization
of HIF-1a in a FOX03-dependent mechanism

Si-Young Cho 1, Miook Cho 2, Juewon Kim 1, Sang Jun Lee 1, and Yousin Suh 2,4,5

1 R&D Unit, Amorepacific Corporation, Yongin-si, Gyeonggi-do, Korea
2 Department of Genetics, Albert Einstein College of Medicine, Bronx NY, USA
3 Department of Pathology, University of Washington, Seattle, WA, USA
4 Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx,NY, USA
5 Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA

Correspondence to :
Sang Jun lee, PhD; Yousin Suh, email:leesjun@amorepacific.com
Yousin Suh, email:yousin.suh@einstein.yu.edu

Syringaresinol, which is one of the components of G-120, activates and increases the number of mitrochondria to strengthen the skeletal muscle cells.

www.elsevier.com/locate/bmcl

Syringaresinol induces mitochondrial biogenesis through activation of PPARβ pathway in skeletal muscle cells

Trung Thanh Thach a, Chan-kyu Leea, Hyun woo Parka, Sang Jun Lee b,c, Sung-Joon Leea,*

a Department of Biotechnology, BK21 Plus Program, Graduate School of Life Sciences and Biotechnology, Deaprtment of Food Bioscience and Technology, College of Life Science and Biotechnology, Korea Unioversity, Seoul 02841, Republic of Korea
b HOLISTICBIO, Pangyoyeok-ro, Bundang-gu, Gyeonggi-do, Republic of Korea
3 Dongguk University Research Institute of Biotechnology and Medical Converged Science, Goyang-si, Gyeonggi-do, Republic of Korea

Anti-diabetic effects of ginseng berry extract supplementation on mice by inhibiting the decrease of longevity related gene expressions and increasing insulin signaling.

www.mdpi.com/journal/nutrients

Nutrients 2015, 7, 3038-3053;

Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insuline Signaling in Mice

Eunhui Seo1,2, Sunmi Kim3, Sang Jun Lee3, Byung-chul Oh2,4, and Hee-Sook Jun1,2,4,*

The effect of ginseng berry extract on men’s sexual functions is surprising. It improved sexual performance as well as erectile prolongation and overall sexual satisfaction. A clinical study on 119 subejcts was conducted at Yonsei University Hospital and Ewha Women’s University Hospital.

www.nature.com/ijir

Effects of Korean Ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

YD Choi, CW Park, J Jang, Sh Kim, HY Jeon, WG Kim, SJ Lee and WS Chung